RPM-1 USES BOTH UBIQUITIN LIGASE AND PHOSPHATASE-BASED MECHANISMS TO REGULATE DLK-1 DURING NEURONAL DEVELOPMENT.

RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.

The Pam/Highwire/RPM-1 (PHR) proteins are key regulators of neuronal development that function in axon extension and guidance, termination of axon outgrowth, and synapse formation.Outside of development, the PHR proteins also regulate axon regeneration and Wallerian degeneration.The SUNGLASSES PHR proteins function in part by acting as ubiquitin li

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Simulation studies on the tomographic reconstruction of the equatorial and low-latitude ionosphere in the context of the Indian tomography experiment: CRABEX

Equatorial ionosphere poses a challenge to any algorithm that is used for tomographic reconstruction because of the phenomena like the Equatorial Ionization Anomaly (EIA) and Equatorial Spread F (ESF).Any tomographic reconstruction of ionospheric density distributions in the equatorial region is not acceptable if it does not image these phenomena,

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Efficacy of Avanafil 15 Minutes after Dosing in Men with Erectile Dysfunction: A Randomized, Double-Blind, Placebo Controlled Study

Phosphodiesterase type 5 (PDE 5) inhibitors are currently first-line medical treatment for erectile dysfunction (ED).PDE 5 inhibitors are differentiated by safety-tolerability profiles and efficacy considerations, such as time to onset and duration Anal Beads of action.The choice of PDE 5 inhibitors in a man with ED is generally based on quality of

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