RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.
The Pam/Highwire/RPM-1 (PHR) proteins are key regulators of neuronal development that function in axon extension and guidance, termination of axon outgrowth, and synapse formation.Outside of development, the PHR proteins also regulate axon regeneration and Wallerian degeneration.The SUNGLASSES PHR proteins function in part by acting as ubiquitin li